U 99363 → 4-[N-Methyl-N-(3-ethoxy-2-pyridinyl)amino]piperidine

HRID 361813

반응식

HRID 361813 반응식
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH3:24])[C:15]2[C:20]([O:21][CH2:22][CH3:23])=[CH:19][CH:18]=[CH:17][N:16]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1.C([O-])=O.[NH4+]>CO.[Pd]>[CH3:24][N:14]([CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)[C:15]1[C:20]([O:21][CH2:22][CH3:23])=[CH:19][CH:18]=[CH:17][N:16]=1

참가 물질

5

반응물 2

HCID 133107U 99363HCID 2723923Ammonium formate

생성물 1

HCID 108473684-[N-Methyl-N-(3-ethoxy-2-pyridinyl)amino]piperidine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 1-benzyl-4-[N-methyl-N-(3-ethoxy-2-pyridinyl)amino]piperidine (EXAMPLE 70, 1.40 g), palladium-on-carbon (10%, 1.4 g) and ammonium formate (813 mg) in methanol (25 ml) is degassed, stirred at 65° for 45 min, cooled to 20°-25°, and filtered to remove catalyst. The filtrate is concentrated under reduced pressure to give the title compound, NMR (CDCl3) 7.83, 6.97, 6.71, 4.02, 3.88, 3.15, 2.88, 2.63, 1.75 and 1.46δ.

후처리

  1. customis degassed
  2. temperaturecooled to 20°-25°
  3. filtrationfiltered
  4. customto remove catalyst
  5. concentrationThe filtrate is concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-4794e628ec764be1bb45fce4998378a0
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05866589

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