1-Benzyl-4-[N-ethyl-N-(3-propylamino-2-pyridinyl)amino]piperidine → 4-[N-ethyl-N-(3-propylamino-2-pyridinyl)amino]piperidine

HRID 361852노트

반응식

HRID 361852 반응식
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH2:25][CH3:26])[C:15]2[C:20]([NH:21][CH2:22][CH2:23][CH3:24])=[CH:19][CH:18]=[CH:17][N:16]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>C(O)C.[OH-].[OH-].[Pd+2]>[CH2:25]([N:14]([CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)[C:15]1[C:20]([NH:21][CH2:22][CH2:23][CH3:24])=[CH:19][CH:18]=[CH:17][N:16]=1)[CH3:26]

참가 물질

5

반응물 2

HCID 675767231-Benzyl-4-[N-ethyl-N-(3-propylamino-2-pyridinyl)amino]piperidineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 108253984-[N-ethyl-N-(3-propylamino-2-pyridinyl)amino]piperidine

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 702Ethanol용매

실험 절차

1-Benzyl-4-[N-ethyl-N-(3-propylamino-2-pyridinyl)amino]piperidine (EXAMPLE 191, 4.34 g, 12.3 mmol) and palladium hydroxide on carbon (2.0 g) in 50 ml ethanol is hydrogenated at 40 p.s.i. hydrogen for 40 hr. Filtration and removal of the solvent gives the title compound, NMR (400 MHz, CDCl3) 7.72, 6.95, 6.83, 3.72, 3.42, 3.09, 2.87, 2.00, 1.66, 1.24, 1.00 and 0.87δ.

후처리

  1. filtrationFiltration and removal of the solvent

출처 및 근거

ORD 기록
ord-cc6f629da7a14fefb33ddcb47bf6452b
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05866589

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