1-Benzyl-4-[N-ethyl-N-(6-fluoro-3-(isopropylamino)-2-pyridinyl)amino]piperidine → 4-[N-Ethyl-N-(6-fluoro-3-(isopropylamino)-2-pyridinyl)amino]piperidine

HRID 361855노트

반응식

HRID 361855 반응식
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH2:26][CH3:27])[C:15]2[C:20]([NH:21][CH:22]([CH3:24])[CH3:23])=[CH:19][CH:18]=[C:17]([F:25])[N:16]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1>C(O)C.[OH-].[Pd+2].[OH-]>[CH2:26]([N:14]([CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)[C:15]1[C:20]([NH:21][CH:22]([CH3:24])[CH3:23])=[CH:19][CH:18]=[C:17]([F:25])[N:16]=1)[CH3:27]

참가 물질

4

반응물 1

HCID 105712191-Benzyl-4-[N-ethyl-N-(6-fluoro-3-(isopropylamino)-2-pyridinyl)amino]piperidine

생성물 1

HCID 675760484-[N-Ethyl-N-(6-fluoro-3-(isopropylamino)-2-pyridinyl)amino]piperidine

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 702Ethanol용매

실험 절차

1-Benzyl-4-[N-ethyl-N-(6-fluoro-3-(isopropylamino)-2-pyridinyl)amino]piperidine (EXAMPLE 196, 2.1 g, 5.76 mmol) is dissolved in ethanol (100 ml) and 0.96 g of palladium hydroxide is added. The reaction is placed on a Parr hydrogenator at 40 psi for 12 hr. Then the reaction is filtered through diatomaceous earth, concentrated under reduced pressure, and used without further purification, NMR (300 MHz, CDCl3) 6.93, 6.55, 4.32, 3.51, 3.11, 3.10-2.95, 2.59, 1.77, 1.55, 1.18 and 0.86δ.

후처리

  1. filtrationThen the reaction is filtered through diatomaceous earth
  2. concentrationconcentrated under reduced pressure
  3. customused without further purification, NMR (300 MHz, CDCl3) 6.93, 6.55, 4.32, 3.51, 3.11, 3.10-2.95, 2.59, 1.77, 1.55, 1.18 and 0

출처 및 근거

ORD 기록
ord-afba2fbf3f1c412ea197430bde958041
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05866589

반응 노트

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