Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(Trifluoromethyl)phenylhydrazine → 5-n-Butyl-2,4-dihydro-2-[2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(Trifluoromethyl)phenylhydrazine | HCID 520800 | — |
| 반응물 | ethyl N-carbethoxyvalerimidate | HCID 53930077 | — |
| 생성물 | 5-n-Butyl-2,4-dihydro-2-[2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one | HCID 135527027 | 66% |
반응 단계
Ethyl-N-carbethoxyvalerimidate (from Example 4, Step B) was reacted with 2-(trifluoromethyl)phenylhydrazine according to the procedure of Example 4, Step C. Flash chromatography of the crude product on silica gel (gradient elution with 0.5-2% MeOH in CH2Cl2) gave a 66% yield of the title compound as white crystals, mp 124°-126° C.; homogeneous by TLC in 19:1 CH2Cl2 --MeOH; mass spectrum (FAB) m/e 286 (M+1)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05411980 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-f003449a7d764dffa16cac6627661d60 |
| 출처 메모 | uspto-grants-1995_05 |