Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 36218생성일: 2026년 10월 24일
5-n-butyl-2,4-dihydro-2-[1-(N-methylcarbamoyl)ethyl]-4-[(2'-cyanobiphenyl-4-yl)methyl]-3H-1,2,4-triazol-3-one → HCID 178441927, 화합물
https://huagongshe.com/ko/reaction/36218
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 5-n-butyl-2,4-dihydro-2-[1-(N-methylcarbamoyl)ethyl]-4-[(2'-cyanobiphenyl-4-yl)methyl]-3H-1,2,4-triazol-3-one | HCID 19939439 | — |
| 반응물 | HCID 178418441 | HCID 178418441 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 178441927 | HCID 178441927 | 43% |
반응 단계
The conversion of 5-n-butyl-2,4-dihydro-2-[1-(N-methylcarbamoyl)ethyl]-4-[(2'-cyanobiphenyl-4-yl)methyl]-3H-1,2,4-triazol-3-one to the corresponding tetrazole was accomplished by the procedure of Example 9, Step E, except that the mixture was stirred at 120° C. for 2 days. After work-up, the residue was taken up in CH2Cl2 and flash chromatographed over silica gel (15 mL for 0.19 mmole, gradient elution using 5-30% MeOH/CH2Cl2 to give the desired compound as a white powder in 43% yield, homogeneous by TLC in 30% MeOH/CH2Cl2, mass spectrum (FAB) 461 (M+1)+, mp 153°-155° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US05411980 |
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| 출처 데이터셋 | uspto-grants-1995_05 |
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| ORD ID | ord-235f2d3ec61644bd9e14d82e7ad6db05 |
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| 출처 메모 | uspto-grants-1995_05 |
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