Cyclopropylamine → HCID 470618, 화합물

반응식

F[C:2]1[C:7](/[CH:8]=[CH:9]\[C:10]2[C:11](F)=[N:12][CH:13]=[CH:14][CH:15]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[CH:17]1([NH2:20])[CH2:19][CH2:18]1>>[CH:17]1([N:20]2[C:2]3[N:3]=[CH:4][CH:5]=[CH:6][C:7]=3[CH:8]=[CH:9][C:10]3[CH:15]=[CH:14][CH:13]=[N:12][C:11]2=3)[CH2:19][CH2:18]1

참가 물질

반응물 2

HCID 69828Cyclopropylamine

HCID 22942261Pyridine, 3,3′-(1Z)-1,2-ethenediylbis[2-fluoro-, (Z)-

생성물 1

HCID 470618HCID 470618, 화합물수율 54.9%

반응 조건

온도: 125 °C

실험 절차

A mixture of Z-1,2-di-(2-fluoropyridinyl)ethylene (0.436 g) and cyclopropylamine (2 g) was heated at 125° C. in a sealed tube for 12 hours. The mixture was cooled and fractionated directly over silica gel to give 11-cyclopropyl-dipyrido[2,3-b:3',2'-f]azepine (0.258 g), mp 184°-185° C.

후처리

temperatureThe mixture was cooled

출처 및 근거

ORD 기록: ord-610ebf02fa134b85954beeb6a44c9775
출처 데이터셋: uspto-grants-1999_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05869482

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