Water → 1-(1-Benzothiophen-3-yl)-2-bromoethan-1-one

HRID 362252

반응식

HRID 362252 반응식
[Br-:1].[Br-].[Br-].C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1.[C:34]([C:37]1[C:38]2[CH:45]=[CH:44][CH:43]=[CH:42][C:39]=2[S:40][CH:41]=1)(=[O:36])[CH3:35].O>O1CCCC1>[Br:1][CH2:35][C:34]([C:37]1[C:38]2[CH:45]=[CH:44][CH:43]=[CH:42][C:39]=2[S:40][CH:41]=1)=[O:36]

참가 물질

5

반응물 3

HCID 962WaterHCID 143163-AcetylbenzothiopheneHCID 17977687Phenyltrimethylammonium bromide dibromide

생성물 1

HCID 27763411-(1-Benzothiophen-3-yl)-2-bromoethan-1-one수율 63.5%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

A solution of phenyltrimethylammonium tribromide (9.6 g) in tetrahydrofuran (20 ml) was added dropwise over 15 minutes at ambient temperature to a stirred solution of 3-acetylbenzo[b]thiophen (5 g) in tetrahydrofuran (50 ml), then the mixture was stirred at ambient temperature for 35 minutes. Water (100 ml) was added, and the resulting solid was collected by filtration, washed with water (2×50 ml) and dried in vacuo at ambient temperature to give 3-(2-bromoacetyl)benzo[b]thiophen as a white solid (2.4 g).

후처리

  1. filtrationthe resulting solid was collected by filtration
  2. washwashed with water (2×50 ml)
  3. customdried in vacuo at ambient temperature

출처 및 근거

ORD 기록
ord-e74de6196c624e248c5ab4cf967bba06
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05869492

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