Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → 3-(Benzo[b]thiophen-3-yl)-5,6-dihydroimidazo[2,1-b]thiazole monohydrobromide dihydrate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Ethylenethiourea | HCID 2723650 | — |
| 반응물 | 1-(1-Benzothiophen-3-yl)-2-bromoethan-1-one | HCID 2776341 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 3-(Benzo[b]thiophen-3-yl)-5,6-dihydroimidazo[2,1-b]thiazole monohydrobromide dihydrate | HCID 68779021 | — |
반응 단계
A mixture of 3-(2-bromoacetyl)benzo[b]thiophen (2.39 g), 2-imidazolidinethione (0.78 g), ethanol (60 ml) and acetic acid (40 ml) was heated under reflux for 18 hours then allowed to cool to ambient temperature. The resulting solid was collected by filtration, washed with ether (2×50 ml), and dried in vacuo at ambient temperature to give 3-(benzo[b]thiophen-3-yl)-5,6-dihydroimidazo[2,1 -b]thiazole monohydrobromide dihydrate as a white solid (2.96 g), m.p. 239°-240° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05869492 |
| 출처 데이터셋 | uspto-grants-1999_02 |
| ORD ID | ord-fd09965459ef41efa16387e585faa295 |
| 출처 메모 | uspto-grants-1999_02 |