3-Acetylbenzothiophene → 1-(1-Benzothiophen-3-yl)-2-bromoethan-1-one

HRID 362254

반응식

HRID 362254 반응식
[Br-:1].[Br-].[Br-].C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1.[C:34]([C:37]1[C:38]2[CH:45]=[CH:44][CH:43]=[CH:42][C:39]=2[S:40][CH:41]=1)(=[O:36])[CH3:35]>O1CCCC1>[Br:1][CH2:35][C:34]([C:37]1[C:38]2[CH:45]=[CH:44][CH:43]=[CH:42][C:39]=2[S:40][CH:41]=1)=[O:36]

참가 물질

4

반응물 2

HCID 143163-AcetylbenzothiopheneHCID 17977687Phenyltrimethylammonium bromide dibromide

생성물 1

HCID 27763411-(1-Benzothiophen-3-yl)-2-bromoethan-1-one수율 105.2%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Phenyltrimethylammonium tribromide (26.32 g) was added in portions over 45 minutes at -5° C. under nitrogen to a stirred solution of 3-acetylbenzo[b]thiophen (12.34 g) in tetrahydrofuran (100 ml), then the mixture was stirred at ambient temperature for 1 hour. The resulting solid was collected by filtration, washed with ether (100 ml), dried in vacuo at ambient temperature, and crystallised from ethanol to give 3-(2-bromoacetyl)benzo[b]thiophen as a white solid (10.9 g).

후처리

  1. filtrationThe resulting solid was collected by filtration
  2. washwashed with ether (100 ml)
  3. customdried in vacuo at ambient temperature
  4. customcrystallised from ethanol

출처 및 근거

ORD 기록
ord-0e71f0129730448488e796e0805809e6
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05869492

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