Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → 3-(Benzo[b]thiophen-3-yl)-5,6-dihydroimidazo[2,1-b]thiazole monohydrobromide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Ethylenethiourea | HCID 2723650 | — |
| 반응물 | 1-(1-Benzothiophen-3-yl)-2-bromoethan-1-one | HCID 2776341 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 3-(Benzo[b]thiophen-3-yl)-5,6-dihydroimidazo[2,1-b]thiazole monohydrobromide | HCID 51071984 | 87.3% |
반응 단계
A mixture of 3-(2-bromoacetyl)benzo[b]thiophen (10.0 g), 2-imidazolidinethione (4.0 g), ethanol (120 ml) and acetic acid (80 ml) was heated under reflux for 24 hours then allowed to cool to ambient temperature. The resulting solid was collected by filtration and dried in vacuo at ambient temperature to give 3-(benzo[b]thiophen-3-yl)-5,6-dihydroimidazo[2,1-b]thiazole monohydrobromide 1.8 hydrate as a white solid (11.6 g), m.p. 227°-229° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05869492 |
| 출처 데이터셋 | uspto-grants-1999_02 |
| ORD ID | ord-4f580d759c6347298f2ae97b8ee1ba13 |
| 출처 메모 | uspto-grants-1999_02 |