Ethanol → 3-(Benzo[b]thiophen-3-yl)-5,6-dihydroimidazo[2,1-b]thiazole monohydrobromide

HRID 362255

반응식

HRID 362255 반응식
[Br:1][CH2:2][C:3]([C:5]1[C:6]2[CH:13]=[CH:12][CH:11]=[CH:10][C:7]=2[S:8][CH:9]=1)=O.[NH:14]1[CH2:18][CH2:17][NH:16][C:15]1=[S:19].C(O)C>C(O)(=O)C>[BrH:1].[S:8]1[CH:9]=[C:5]([C:3]2[N:16]3[CH2:17][CH2:18][N:14]=[C:15]3[S:19][CH:2]=2)[C:6]2[CH:13]=[CH:12][CH:11]=[CH:10][C:7]1=2

참가 물질

5

반응물 3

HCID 702EthanolHCID 2723650EthylenethioureaHCID 27763411-(1-Benzothiophen-3-yl)-2-bromoethan-1-one

생성물 1

HCID 510719843-(Benzo[b]thiophen-3-yl)-5,6-dihydroimidazo[2,1-b]thiazole monohydrobromide수율 87.3%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 3-(2-bromoacetyl)benzo[b]thiophen (10.0 g), 2-imidazolidinethione (4.0 g), ethanol (120 ml) and acetic acid (80 ml) was heated under reflux for 24 hours then allowed to cool to ambient temperature. The resulting solid was collected by filtration and dried in vacuo at ambient temperature to give 3-(benzo[b]thiophen-3-yl)-5,6-dihydroimidazo[2,1-b]thiazole monohydrobromide 1.8 hydrate as a white solid (11.6 g), m.p. 227°-229° C.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 24 hours
  3. filtrationThe resulting solid was collected by filtration
  4. customdried in vacuo at ambient temperature

출처 및 근거

ORD 기록
ord-4f580d759c6347298f2ae97b8ee1ba13
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05869492

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