1-(1-Benzofuran-3-yl)ethan-1-one → 1-(Benzofuran-3-yl)-2-bromoethanone

HRID 362257

반응식

HRID 362257 반응식
[Br-:1].[Br-].[Br-].C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1.[C:34]([C:37]1[C:38]2[CH:45]=[CH:44][CH:43]=[CH:42][C:39]=2[O:40][CH:41]=1)(=[O:36])[CH3:35]>O1CCCC1>[Br:1][CH2:35][C:34]([C:37]1[C:38]2[CH:45]=[CH:44][CH:43]=[CH:42][C:39]=2[O:40][CH:41]=1)=[O:36]

참가 물질

4

반응물 2

HCID 112866121-(1-Benzofuran-3-yl)ethan-1-oneHCID 17977687Phenyltrimethylammonium bromide dibromide

생성물 1

HCID 27765801-(Benzofuran-3-yl)-2-bromoethanone수율 27.4%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

A solution of phenyltrimethylammonium tribromide (2.47 g) in tetrahydrofuran (20 ml) was added dropwise at ambient temperature under nitrogen over 5 minutes to a stirred solution of 3-acetylbenzo[b]furan (1 g) in tetrahydrofuran (20 ml), then the mixture was stirred at ambient temperature for a further 1.5 hours, filtered, and the solvent removed in vacuo. The residue was triturated with ether, and the resulting solid was collected by filtration and dried in vacuo at ambient temperature to give 3-(2-bromoacetyl)benzo[b]furan as an off-white solid (0.25 g).

후처리

  1. filtrationfiltered
  2. customthe solvent removed in vacuo
  3. customThe residue was triturated with ether
  4. filtrationthe resulting solid was collected by filtration
  5. customdried in vacuo at ambient temperature

출처 및 근거

ORD 기록
ord-10b5b665c38b46309fa8f6f6837d9876
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05869492

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