Ethanol → 3-(Benzo[b]furan-3-yl)-5,6-dihydroimidazo[2,1-b]thiazole monohydrobromide monohydrate

HRID 362258

반응식

HRID 362258 반응식
[Br:1][CH2:2][C:3]([C:5]1[C:6]2[CH:13]=[CH:12][CH:11]=[CH:10][C:7]=2[O:8][CH:9]=1)=[O:4].[NH:14]1[CH2:18][CH2:17][NH:16][C:15]1=[S:19].C(O)C>C(O)(=O)C>[OH2:4].[BrH:1].[O:8]1[CH:9]=[C:5]([C:3]2[N:16]3[CH2:17][CH2:18][N:14]=[C:15]3[S:19][CH:2]=2)[C:6]2[CH:13]=[CH:12][CH:11]=[CH:10][C:7]1=2

참가 물질

5

반응물 3

HCID 702EthanolHCID 2723650EthylenethioureaHCID 27765801-(Benzofuran-3-yl)-2-bromoethanone

생성물 1

HCID 702862843-(Benzo[b]furan-3-yl)-5,6-dihydroimidazo[2,1-b]thiazole monohydrobromide monohydrate수율 40.6%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 3-(2-bromoacetyl)benzo[b]furan (0.25 g), 2-imidazolidinethione (0.11 g), ethanol (30 ml) and acetic acid (20 ml) was heated under reflux for 20 hours, then allowed to cool to ambient temperature. The resulting solid was collected by filtration, washed with ether, and dried in vacuo at ambient temperature to give 3-(benzo[b]furan-3-yl)-5,6-dihydroimidazo[2,1-b]thiazole monohydrobromide monohydrate as a white solid (0.145 g), m.p. 242°-244° C.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 20 hours
  3. filtrationThe resulting solid was collected by filtration
  4. washwashed with ether
  5. customdried in vacuo at ambient temperature

출처 및 근거

ORD 기록
ord-5ea882d0114b46a19725bfebd4a0ef53
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05869492

연결된 노트

불러오는 중…