Ethanol → HCID 70284500, 화합물

HRID 362266노트

반응식

HRID 362266 반응식
[Br:1][CH2:2][C:3]([C:5]1[C:6]2[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:7]=2[S:8][CH:9]=1)=O.[NH:15]1[CH2:19][CH2:18][NH:17][C:16]1=[S:20].C(O)C>C(O)(=O)C>[BrH:1].[Cl:14][C:12]1[CH:11]=[CH:10][C:7]2[S:8][CH:9]=[C:5]([C:3]3[N:17]4[CH2:18][CH2:19][N:15]=[C:16]4[S:20][CH:2]=3)[C:6]=2[CH:13]=1

참가 물질

5

반응물 3

HCID 702EthanolHCID 2723650EthylenethioureaHCID 57175247HCID 57175247, 화합물

생성물 1

HCID 70284500HCID 70284500, 화합물수율 57.4%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of the crude 3-(2-bromoacetyl)-5-chlorobenzo[b]thiophen (4.2 g), 2-imidazolidinethione (1 g), ethanol (15 ml) and acetic acid (10 ml) was heated under reflux under nitrogen for 18 hours, then allowed to cool to ambient temperature. The resulting solid was collected by filtration, washed with ethanol (15 ml), and dried in vacuo to give 3-(5-chlorobenzo[b]thiophen-3-yl)-5,6-dihydroimidazo[2,1-b]thiazole monohydrobromide as a white solid (2.1 g), m.p. 286°-288° C. (dec.).

후처리

  1. temperaturewas heated
  2. temperatureunder reflux under nitrogen for 18 hours
  3. filtrationThe resulting solid was collected by filtration
  4. washwashed with ethanol (15 ml)
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-018a43fac15a4943bd2445c6946d8fdc
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05869492

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