Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,4-Dimethylbenzoyl chloride → N-[4-[(6,11-Dihydro-5H-dibenz[b,e]azepin-5-yl)carbonyl]phenyl]2,4-dimethylbenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,4-Dimethylbenzoyl chloride | HCID 140867 | — |
| 반응물 | 5-(4-Aminobenzoyl)-6,11-dihydro-5H-dibenz[b,e]azepine | HCID 15410467 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-[4-[(6,11-Dihydro-5H-dibenz[b,e]azepin-5-yl)carbonyl]phenyl]2,4-dimethylbenzamide | HCID 15307977 | 56.7% |
반응 단계
As described in Example 9, 0.471 g (1.5 mmol) of 5-(4-aminobenzoyl)-6,11-dihydro-5H-dibenz[b,e]azepine is reacted with 0.303 g (1.8 mmol) of 2,4-dimethylbenzoyl chloride in 10 ml of dichloromethane. The product is recrystallized from hexane-dichloromethane to give 0.38 g of crystals, m.p. 197-199° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05869483 |
| 출처 데이터셋 | uspto-grants-1999_02 |
| ORD ID | ord-ee5bc1e4a0f142a3868a4e49a867a703 |
| 출처 메모 | uspto-grants-1999_02 |