2-Methylfuran-3-carbonyl chloride → N-[4-[(6,11-Dihydro-5H-dibenz[b,e]azepin-5-yl)carbonyl]phenyl]-2-methyl-3-furanecarboxamide

HRID 362397노트

반응식

HRID 362397 반응식
[CH3:1][C:2]1[O:3][CH:4]=[CH:5][C:6]=1[C:7](Cl)=[O:8].[NH2:10][C:11]1[CH:33]=[CH:32][C:14]([C:15]([N:17]2[CH2:23][C:22]3[CH:24]=[CH:25][CH:26]=[CH:27][C:21]=3[CH2:20][C:19]3[CH:28]=[CH:29][CH:30]=[CH:31][C:18]2=3)=[O:16])=[CH:13][CH:12]=1>>[CH:28]1[C:19]2[CH2:20][C:21]3[CH:27]=[CH:26][CH:25]=[CH:24][C:22]=3[CH2:23][N:17]([C:15]([C:14]3[CH:13]=[CH:12][C:11]([NH:10][C:7]([C:6]4[CH:5]=[CH:4][O:3][C:2]=4[CH3:1])=[O:8])=[CH:33][CH:32]=3)=[O:16])[C:18]=2[CH:31]=[CH:30][CH:29]=1

참가 물질

3

반응물 2

HCID 27598502-Methylfuran-3-carbonyl chlorideHCID 154104675-(4-Aminobenzoyl)-6,11-dihydro-5H-dibenz[b,e]azepine

생성물 1

HCID 67625920N-[4-[(6,11-Dihydro-5H-dibenz[b,e]azepin-5-yl)carbonyl]phenyl]-2-methyl-3-furanecarboxamide

실험 절차

As described for Example 9, 2-methyl-3-furanecarbonyl chloride is reacted with 5-(4-aminobenzoyl)-6,11-dihydro-5H-dibenz[b,e]azepine to give the product. Recrystallization from dichloromethane-hexane gives crystals, m.p. 202°-204° C.

후처리

  1. customto give the product
  2. customRecrystallization from dichloromethane-hexane
  3. customgives crystals, m.p. 202°-204° C.

출처 및 근거

ORD 기록
ord-c4968a8308c44d8c97613293f8685e9d
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05869483

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