Tert-Butylamine → N-tert-butyl-4-propylbenzenesulfonamide

HRID 36265

반응식

HRID 36265 반응식
[CH2:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[CH:6][CH:5]=1)[CH2:2][CH3:3].[C:14]([NH2:18])([CH3:17])([CH3:16])[CH3:15]>C(Cl)Cl>[C:14]([NH:18][S:10]([C:7]1[CH:8]=[CH:9][C:4]([CH2:1][CH2:2][CH3:3])=[CH:5][CH:6]=1)(=[O:12])=[O:11])([CH3:17])([CH3:16])[CH3:15]

참가 물질

4

반응물 2

HCID 6385Tert-ButylamineHCID 27372224-N-Propylbenzenesulphonyl chloride

생성물 1

HCID 6470063N-tert-butyl-4-propylbenzenesulfonamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 4-n-propylbenzenesulfonyl chloride (Lancaster) in anhydrous CH2Cl2 (0.5M solution) cooled to 0° C. under N2 was added t-butylamine (2.2 equiv) slowly through a dropping funnel. After complete addition, the reaction was stirred at room temperature for 12 hours. The CH2Cl2 was removed under reduced pressure, and the residue was extracted into ether and washed with 2N NaOH, H2O and brine. The organic phase was dried over anhydrous MgSO4 and concentrated in vacuo to afford the titled product; Rf =0.46 (3:1 hexane-EtOAc).

후처리

  1. additionAfter complete addition
  2. customThe CH2Cl2 was removed under reduced pressure
  3. extractionthe residue was extracted into ether
  4. washwashed with 2N NaOH, H2O and brine
  5. dry with materialThe organic phase was dried over anhydrous MgSO4
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-ccbebb7318f94b96b6a561d0473d3f04
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05411980

연결된 노트

불러오는 중…