3-(4-Fluorophenyl)-2-propenoic acid → 3-(4-Fluorophenyl)propionic acid

HRID 362804

반응식

HRID 362804 반응식
[F:1][C:2]1[CH:12]=[CH:11][C:5]([CH:6]=[CH:7][C:8]([OH:10])=[O:9])=[CH:4][CH:3]=1>[Pd].C(O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH2:7][C:8]([OH:10])=[O:9])=[CH:11][CH:12]=1

참가 물질

4

반응물 1

HCID 980703-(4-Fluorophenyl)-2-propenoic acid

생성물 1

HCID 1363023-(4-Fluorophenyl)propionic acid수율 91%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of 4-fluorocinnamic acid (300.0 g, 1.8 mol, Aldrich) and 5% palladium on carbon (9.0 g) in ethanol (3 L) was hydrogenated at atmospheric pressure and room temperature for 4.5 h. The mixture was filtered through Celite (diatomaceous earth) and the filtrate was concentrated in vacuo to give 275.1 g (91%) of 3-(4-fluorophenyl)propionic acid as a white solid: m.p., 86°-88° C.;

후처리

  1. filtrationThe mixture was filtered through Celite (diatomaceous earth)
  2. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-9fffec0f198b4e048795124dd3fd9a26
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05872118

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