Oxalyl chloride → HCID 23293589, 화합물

HRID 362854노트

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HRID 362854 반응식
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:16])([CH3:15])[CH2:7]/[C:8]/2=[CH:11]\[C:12](O)=[O:13])=[CH:4][CH:3]=1.C(Cl)(=O)C([Cl:20])=O>ClCCl>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:16])([CH3:15])[CH2:7]/[C:8]/2=[CH:11]\[C:12]([Cl:20])=[O:13])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 23293609Acetic acid, (6-fluoro-2,3-dihydro-3,3-dimethyl-1H-inden-1-ylidene)-, (2E)-

생성물 1

HCID 23293589HCID 23293589, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

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온도
25 °C

실험 절차

To an ice cold, stirred suspension of (E)-2-(6-fluoro-3,3-dimethyl-1-indanylidene)acetic acid (9.0 g, 0.0409 mol) in dichloromethane (200 ml) was added oxalyl chloride (15.6 g, 0.123 mol, Aldrich). The stirring suspension was allowed to warm to 25° C. during 2 h. The resulting solution was concentrated by spin evaporation in vacuo with the addition of dichloromethane (4×75 ml) to give (E)-2-(6-fluoro-3,3-dimethyl-1-indanylidene)acetyl chloride as an uncharacterized oil. Dichloromethane (approximately 70 g) was added to dissolve this residual oil and the resulting solution was divided equally and used without other purification in Examples 15i, 16 and 17.

후처리

  1. concentrationThe resulting solution was concentrated by spin evaporation in vacuo with the addition of dichloromethane (4×75 ml)

출처 및 근거

ORD 기록
ord-1e2a841467e841738217c28190605767
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05872118

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