Aluminium lithium hydride → 4-(N-methylamino)methyl-1-diphenylmethylpiperidine

HRID 362904노트

반응식

HRID 362904 반응식
[CH:1]([NH:3][CH2:4][CH:5]1[CH2:10][CH2:9][N:8]([CH:11]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:7][CH2:6]1)=O.[H-].[H-].[H-].[H-].[Li+].[Al+3]>>[CH3:1][NH:3][CH2:4][CH:5]1[CH2:10][CH2:9][N:8]([CH:11]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:7][CH2:6]1

참가 물질

3

반응물 2

HCID 21226445Aluminium lithium hydrideHCID 539859804-(N-formylamino)methyl-1-diphenylmethylpiperidine

생성물 1

HCID 537192494-(N-methylamino)methyl-1-diphenylmethylpiperidine수율 100%

실험 절차

Step 2): In a similar manner to that of Preparation 1 step 2), 4-(N-formylamino)methyl-1-diphenylmethylpiperidine was reduced by LiAlH4 to give 4-(N-methylamino)methyl-1-diphenylmethylpiperidine; yield 100%.

출처 및 근거

ORD 기록
ord-0ae05bb9987943fcad3ff42aa67332ee
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05872115

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