Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Bromo-2-fluorotoluene → 3-Fluoro-4-methyl-2'-(N-t-butylsulfamoyl)biphenyl
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Bromo-2-fluorotoluene | HCID 171040 | — |
| 반응물 | Boronic acid, B-(2-(((1,1-dimethylethyl)amino)sulfonyl)phenyl)- | HCID 4997616 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 생성물 | 3-Fluoro-4-methyl-2'-(N-t-butylsulfamoyl)biphenyl | HCID 10087424 | 92% |
반응 단계
The palladium(0)-catalyzed coupling of 4-bromo-2-fluorotoluene with 2-(N-t-butylsulfamoyl)phenylboronic acid was carried out according to the procedure of Example 76, Step F. Purification of the crude product by flash chromatography (elution with hexane-EtOAc) gave a 92% yield of the title compound as an off-white foam (TLC in 4:1 hexane-EtOAc); mass spectrum (FAB) m/e 322 (M+1)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05411980 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-3d6b6f4d22314c4ab5ae4e244b8af097 |
| 출처 메모 | uspto-grants-1995_05 |