4-(3-Fluorophenyl)-3-buten-1-ol → 3-Fluoro-benzenebutanol

HRID 363081노트

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HRID 363081 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH2:10][CH2:11][OH:12])[CH:5]=[CH:6][CH:7]=1.[H][H]>[C].[Pd].C(OCC)(=O)C>[F:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][CH2:10][CH2:11][OH:12])[CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 2

HCID 536388864-(3-Fluorophenyl)-3-buten-1-olHCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 540408183-Fluoro-benzenebutanol수율 89.5%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 8857Ethyl Acetate용매

실험 절차

In a reaction vessel were placed 0.53 g of 4-(3-fluorophenyl)-3-buten-1-ol and 50 ml of ethyl acetate, and the air in the vessel was exchanged for nitrogen. Then, 0.1 g of 10% palladium carbon was added thereto, and the nitrogen in the vessel was exchanged for hydrogen, followed by vigorous stirring at room temperature for 24 hours. After the hydrogen in the vessel was exchanged for nitrogen, the reaction solution was filtered through a celite bed, and the filtrate was concentrated. The residue was subjected to silica gel chromatography, which afforded 0.48 g of 4-(3-fluorophenyl)-1-butanol.

후처리

  1. customIn a reaction vessel were placed
  2. filtrationthe reaction solution was filtered through a celite bed
  3. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-329321572bed4df2bf1df618f2db5072
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05872137

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