Potassium Carbonate → 3-Chloro-4-[3-(4-trifluoromethylphenoxy) propyloxy]-5-methyl-1-(3,3-dichloro-2-propenyloxy)benzene

HRID 363086노트

반응식

HRID 363086 반응식
Br[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([F:15])([F:14])[F:13])=[CH:8][CH:7]=1.BrCCCOC1C=CC(OC(F)(F)F)=CC=1.C(=O)([O-])[O-].[K+].[K+].[Cl:38][C:39]1[CH:44]=[C:43]([O:45][CH2:46][CH:47]=[C:48]([Cl:50])[Cl:49])[CH:42]=[C:41]([CH3:51])[C:40]=1[OH:52]>CN(C)C=O.C(OCC)C>[Cl:38][C:39]1[CH:44]=[C:43]([O:45][CH2:46][CH:47]=[C:48]([Cl:49])[Cl:50])[CH:42]=[C:41]([CH3:51])[C:40]=1[O:52][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([F:15])([F:14])[F:13])=[CH:8][CH:7]=1

참가 물질

7

반응물 4

HCID 11430Potassium CarbonateHCID 11781023Benzene, 1-(3-bromopropoxy)-4-(trifluoromethyl)-HCID 136722751-(3-Bromopropoxy)-4-(trifluoromethoxy)benzeneHCID 185046952-Chloro-6-methyl-4-(3,3-dichloro-2-propenyloxy)phenol

생성물 1

HCID 538030523-Chloro-4-[3-(4-trifluoromethylphenoxy) propyloxy]-5-methyl-1-(3,3-dichloro-2-propenyloxy)benzene수율 94.9%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6228Dimethylformamide용매

실험 절차

First, 0.35 g of 1-(3-bromopropyloxy)-4-trifluoromethylbenzene (prepared in the same manner as described above for 1-(3-bromopropyloxy)-4-trifluoromethoxybenzene) and 0.2 g of potassium carbonate were dissolved in 100 ml of N,N-dimethylformamide, to which 0.3 g of 2-chloro-6-methyl-4-(3,3-dichloro-2-propenyloxy)phenol was added, and the mixture was stirred at room temperature for 24 hours. The reaction mixture was mixed with 200 ml of diethyl ether, washed with water, dried with anhydrous magnesium sulfate, and concentrated to obtain a crude product. The crude product was subjected to silica gel chromatography, which afforded 0.50 g of 3-chloro-4-[3-(4-trifluoromethylphenoxy) propyloxy]-5-methyl-1-(3,3-dichloro-2-propenyloxy)benzene (94% yield), nD23.0 1.5330.

후처리

  1. additionwas added
  2. washwashed with water
  3. dry with materialdried with anhydrous magnesium sulfate
  4. concentrationconcentrated
  5. customto obtain a crude product

출처 및 근거

ORD 기록
ord-ea71162892f44dcabd4cc1a971eff7e4
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05872137

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