Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Anthranilic Acid → 2-(Octanoylamino)benzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Anthranilic Acid | HCID 227 | — |
| 반응물 | Chloride | HCID 312 | — |
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-(Octanoylamino)benzoic acid | HCID 4157220 | 79.4% |
반응 단계
Anthranilic acid was dissolved in a mixed solvent containing pyridine and tetrahydrofuran (THF) in 5:5 ratio and a THF solution of n-caprioyl chloride was dropped to the solution during several hours for reaction. After the reaction, hydrochloric acid was added to the reaction mixture. Pyridine hydrochloride was filtered and the solvent was removed. N-n-octanoylanthranilic acid was obtained from the remaining reactant after the purification by column chromatography with the yield of 79.4%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05413794 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-26de8cb6b8ab4be3a4b1393e37538166 |
| 출처 메모 | uspto-grants-1995_05 |