Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → N-(2(R)-hydroxy-1(S)-indanyl)-3-phenylpropaneamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Benzenepropanoyl chloride | HCID 64801 | — |
| 반응물 | (1S,2R)-(-)-1-Amino-2-indanol | HCID 9866743 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-(2(R)-hydroxy-1(S)-indanyl)-3-phenylpropaneamide | HCID 22857039 | — |
반응 단계
To a cold (0° C.) solution of methylene chloride (30 ml) containing 2(R)-hydroxy-1(S)-aminoindane (750 mg, 5.0 mmol) and triethylamine (606 mg, 6.0 mmol) was added a solution of hydrocinnamoyl chloride (843 mg, 5.0 mmol) in 5 ml of methylene chloride. After 2 hr the reaction was poured into a separatory funnel containing 50 ml of methylene chloride and washed with 10% citric acid solution (2×30 ml). The organic layer was dried, filtered and concentrated to afford a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05413999 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-c6b393091b0d4e87a9a90ad1c747c4d7 |
| 출처 메모 | uspto-grants-1995_05 |