Diethyl Ether → HCID 135537121, 화합물

HRID 363361노트

반응식

HRID 363361 반응식
Cl[C:2]1[CH:7]=[C:6]([OH:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH2:17][CH3:18])[N:3]=1.[CH2:19]([NH2:21])[CH3:20].C(OCC)C>C(O)C>[CH2:19]([NH:21][C:2]1[N:3]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH2:17][CH3:18])[NH:5][C:6](=[O:8])[CH:7]=1)[CH3:20]

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 6341EthylamineHCID 178458304HCID 178458304, 화합물

생성물 1

HCID 135537121HCID 135537121, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

4-Chloro-6-hydroxy-2-(2-propoxyphenyl)-pyrimidine (0.66 g) and ethylamine in ethanol (33%, 20 ml) was heated at 90° C. in a pressure vessel for 16 hours. The cooled reaction mixture was evaporated under reduced pressure to yield an oil which solidified on trituration with diethyl ether. The residue was recrystallized from isopropanol:diethyl ether, washed with water and recrystallized from isopropanol:water to yield the title compound, 0.47 g, m.p. 187°-80° C.

후처리

  1. customThe cooled reaction mixture
  2. customwas evaporated under reduced pressure
  3. customto yield an oil which
  4. customThe residue was recrystallized from isopropanol
  5. washdiethyl ether, washed with water
  6. customrecrystallized from isopropanol

출처 및 근거

ORD 기록
ord-4f5a7f92a2b84c1b8402292506249c9e
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05874440

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