Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Bromobenzoic acid → 1-Bromo-3-tert-butylbenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Bromobenzoic acid | HCID 11456 | — |
| 반응물 | 1-(tert-Butyl)-3-ethynylbenzene | HCID 14989667 | — |
| 반응물 | Trimethylaluminum | HCID 16682925 | — |
| 용매 | Hexane | HCID 8058 | — |
| 생성물 | 1-Bromo-3-tert-butylbenzene | HCID 343798 | — |
반응 단계
Reaction Scheme 4 discloses a specific synthetic route to 3-tert-butylphenyl ethyne (Compound 22) starting with meta bromobenzoic acid (Compound 23), which is treated with trimethylaluminum in hexane to yield 3-tert-butyl bromobenzene (Compound 24). 3-Tert-butyl bromobenzene 24 is thereafter converted into the ethyne derivative 22 through the trimethylsilyl ethyne intermediate 25 in steps similar to the steps described in connection with Reaction Scheme 3.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05414007 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-1545945aa4924efca8fa5810dddf53f3 |
| 출처 메모 | uspto-grants-1995_05 |