Water → Ethyl 2-(1,3-dioxoisoindolin-2-yl)-2-fluoroacetate
반응식
Br[CH:2]([F:8])[C:3]([O:5][CH2:6][CH3:7])=[O:4].[C:9]1([C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:12][O:11]1)=[O:10].[K].CCOCC.O.C[N:27](C)C=O>>[O:10]=[C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:12](=[O:11])[N:27]1[CH:2]([F:8])[C:3]([O:5][CH2:6][CH3:7])=[O:4]참가 물질
6
반응 조건
- 온도
- 80 °C
실험 절차
A stirred mixture of ethyl bromofluoroacetate (1.0 g, 5.4 mmol) and potassium phthalide (1.0 g, 5.4 mmol) in dimethylformamide (10 mL) is heated at 80° C. for 3 hours. The mixture is stirred with ether (50 mL) and water (50 mL) and the organic layer then washed with water and brine (30 mL each), and dried over sodium sulfate. The solvent is removed in vacuo to give ethyl 2-(1,3-dioxoisoindolin-2-yl)-2-fluoroacetate which is further purified through chromatography.
후처리
- washthe organic layer then washed with water and brine (30 mL each)
- dry with materialdried over sodium sulfate
- customThe solvent is removed in vacuo
출처 및 근거
- ORD 기록
- ord-adc2f0d352cc4ef2ad1036de8b178de2
- 출처 데이터셋
- uspto-grants-1999_02
- 특허 번호
- US05874448
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