Tetrahydrofuran → HCID 15839665, 화합물

HRID 363526노트

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HRID 363526 반응식
[C:1]([C:3]1[CH:18]=[CH:17][C:6]([CH2:7][N:8]2[C:12]([CH2:13][C:14]([NH2:16])=[S:15])=[CH:11][N:10]=[CH:9]2)=[CH:5][CH:4]=1)#[N:2].C1COCC1.[CH3:24][N:25]1[CH:29]=[CH:28][CH:27]=[C:26]1[C:30](=O)[CH2:31]Br>CCOC(C)=O>[C:1]([C:3]1[CH:18]=[CH:17][C:6]([CH2:7][N:8]2[C:12]([CH2:13][C:14]3[S:15][C:30]([C:26]4[N:25]([CH3:24])[CH:29]=[CH:28][CH:27]=4)=[CH:31][N:16]=3)=[CH:11][N:10]=[CH:9]2)=[CH:5][CH:4]=1)#[N:2]

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 124077412-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethan-1-oneHCID 53772023HCID 53772023, 화합물

생성물 1

HCID 15839665HCID 15839665, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

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온도
50 °C

실험 절차

To a 25 mL round bottomed flask with a stirring bar reflux condenser and an argon inlet is added 1-(4-cyanobenzyl)-5-(aminothiocarbonyl)methyl-1H-imidazole (0.12 g, 0.468 mmol), dry THF (10 mL), and N-methyl-a-bromoacetylpyrrole (0.098 g, 0.491 mmol). This mixture is heated at 50° C. for 7 hours. The cooled reaction mixture is diluted with EtOAc and washed sucessively with aq. NaHCO3, water, and brine. The organic extract is dried, (MgSO4) and the solvent is evaporated in vacuo. The residue is purified by chromatography to afford the title compound.

후처리

  1. temperatureTo a 25 mL round bottomed flask with a stirring bar reflux condenser and an argon inlet
  2. customThe cooled reaction mixture
  3. washwashed sucessively with aq. NaHCO3, water, and brine
  4. extractionThe organic extract
  5. customis dried
  6. custom(MgSO4) and the solvent is evaporated in vacuo
  7. customThe residue is purified by chromatography

출처 및 근거

ORD 기록
ord-ec83389ff2e9450381e7f7d96dca43f4
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05874452

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