Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyrazinamide → 2-Pyrazinecarboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyrazinamide | HCID 1046 | — |
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 용매 | Thionyl Chloride | HCID 24386 | — |
| 생성물 | 2-Pyrazinecarboxylic acid | HCID 1047 | 111.6% |
반응 단계
Thionyl chloride (10 mL) is added to a 25 mL round bottom flask in an ice bath. To the flask is added 800 mg (6.5 mmole) of 2-Pyrazinecarboxylic acid 74, and the mixture stirred for 5 minutes. Dimethyl formamide (1.02 g mg, 14 mmole) is added in a single portion, and the orange/red solution stirred for 90 minutes. The solvents are removed under reduced pressure to give 80 (0.900 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05874587 |
| 출처 데이터셋 | uspto-grants-1999_02 |
| ORD ID | ord-985d28b7d2a04e548b931597ed5ae8cb |
| 출처 메모 | uspto-grants-1999_02 |