Potassium Hydroxide → 2-Benzylacrylic Acid

HRID 36374

반응식

HRID 36374 반응식
[CH2:1]=[C:2]([CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:3]([O:5]CC)=[O:4].[OH-].[K+]>CO>[CH2:1]=[C:2]([CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:3]([OH:5])=[O:4]

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 11084648Ethyl 2-benzylacrylate

생성물 1

HCID 3035712-Benzylacrylic Acid수율 71%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The ethyl α-methylenebenzenepropanoate of Step 8 (4.6 g, 24.3 mmol) was dissolved in methanol (12 mL) and then reacted with 2N potassium hydroxide (24 mL) solution. The mixture was stirred at room temperature for 4 hours and concentrated by evaporation. The residue was diluted with water and washed with ether. The aqueous layer was acidified to pH 2 with 1N HCl, and then extracted with ethyl acetate. The extracts were dried (MgSO4) and evaporated to give the title compound as colorless oil (2.8 g, 66% yield). 1H NMR: 300MHz spectrum consistent with proposed structure.

후처리

  1. concentrationconcentrated by evaporation
  2. additionThe residue was diluted with water
  3. washwashed with ether
  4. extractionextracted with ethyl acetate
  5. dry with materialThe extracts were dried (MgSO4)
  6. customevaporated

출처 및 근거

ORD 기록
ord-c2667c1c1f0b427fbd77fc2f264f3da1
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05414018

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