Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Anhydride → Baccatin Iii
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | 10-deacetylbaccatin III | HCID 154272 | — |
| 반응물 | Dichloromethane methanol | HCID 21226129 | — |
| 촉매 | Scandium(III) triflate | HCID 2734571 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Baccatin Iii | HCID 65366 | 58% |
| 생성물 | 10-deacetylbaccatin III | HCID 154272 | 18% |
반응 단계
To a solution of 50 mg (91.9 μmol) of 10-deacetylbaccatin III and 13 μL (1.5 eq.) of acetic anhydride in 2.0 mL of freshly distilled tetrahydrofuran 100 μL of a solution of 4.5 mg of commercial scandium trifluoromethanesulfonate in 1.0 mL of tetrahydrofuran was added. The reaction mixture was stirred at room temperature for 48 hours. Usual workup and isolation of the product by means of preparative TLC (Silica 60, CH2Cl2/MeOH 10:1) afforded 9 mg of unreacted 10-deacetylbaccatin III (18%) along with 31 mg of baccatin III (58%). 1H-NMR and Rf-value (TLC) were in accordance with the product from example 1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05874595 |
| 출처 데이터셋 | uspto-grants-1999_02 |
| ORD ID | ord-8d7679915d9c41e98caf514da8929edb |
| 출처 메모 | uspto-grants-1999_02 |