2-Chloropyridine → 3-(1-Benzofuran-2-YL)pyridine

HRID 363886노트

반응식

HRID 363886 반응식
Clc1ccccn1.OB(O)c1cc2ccccc2o1>C1CCC2=NCCCN2CC1.C1CCOC1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CS(=O)(=O)[O][Pd][c]1ccccc1-c1ccccc1N.O>c1cncc(-c2cc3ccccc3o2)c1

참가 물질

10

반응물 2

HCID 79772-ChloropyridineHCID 2776266Benzo[b]furan-2-boronic acid

생성물 1

HCID 218560443-(1-Benzofuran-2-YL)pyridine수율 0.2%

시약·촉매·용매 7

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-ene시약HCID 178422002HCID 178422002, 화합물촉매HCID 962Water용매HCID 8028Tetrahydrofuran용매5회HCID 180Acetone후처리HCID 931Naphthalene내부 표준HCID 962Water후처리

반응 조건

온도
110 °C

후처리

  1. additionAs soon as the slug leaves the reactor and is detected at PS2,a quench solution volume equal to the reaction slug volume(prepared slug volume + base injection volume) is injected into the reaction slug

출처 및 근거

ORD 기록
ord-3cc689637a8d4cc3a1bec094b126abdc
출처 데이터셋
Reizman Suzuki Cross-Coupling
원본 링크
출처 보기

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