2-Chloropyridine → 3-(1-Benzofuran-2-YL)pyridine

HRID 363918노트

반응식

HRID 363918 반응식
Clc1ccccn1.OB(O)c1cc2ccccc2o1>C1CCC2=NCCCN2CC1.C1CCOC1.COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.CS(=O)(=O)[O][Pd][c]1ccccc1-c1ccccc1N.O>c1cncc(-c2cc3ccccc3o2)c1

참가 물질

10

반응물 2

HCID 79772-ChloropyridineHCID 2776266Benzo[b]furan-2-boronic acid

생성물 1

HCID 218560443-(1-Benzofuran-2-YL)pyridine수율 88.8%

시약·촉매·용매 7

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-ene시약HCID 178491332HCID 178491332, 화합물촉매HCID 962Water용매HCID 8028Tetrahydrofuran용매5회HCID 180Acetone후처리HCID 931Naphthalene내부 표준HCID 962Water후처리

반응 조건

온도
110 °C

후처리

  1. additionAs soon as the slug leaves the reactor and is detected at PS2,a quench solution volume equal to the reaction slug volume(prepared slug volume + base injection volume) is injected into the reaction slug

출처 및 근거

ORD 기록
ord-ce9f2922ab734335a31629f7459f6007
출처 데이터셋
Reizman Suzuki Cross-Coupling
원본 링크
출처 보기

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