Pyridine → Pyridazinyl carbamate

HRID 363987

반응식

HRID 363987 반응식
Cl[C:2]([O:4][C:5]1C=C[CH:8]=[CH:7][CH:6]=1)=[O:3].[N:11]1C=CC=C(N)[N:12]=1.[N:18]1C=CC=CN=1.N1C=CC=CC=1>C(N(CC)CC)C>[C:2](=[O:3])([O:4][C:5]1[N:11]=[N:12][CH:8]=[CH:7][CH:6]=1)[NH2:18]

참가 물질

6

반응물 4

HCID 1049PyridineHCID 9259PyridazineHCID 15891Phenyl chloroformateHCID 230373Aminopyridazine

생성물 1

HCID 20239911Pyridazinyl carbamate

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

The reaction of a haloformate, such as phenyl chloroformate, and a pyridazineamine generally is carried out by combining a slight excess of haloformate with the pyridazine in an organic solvent, such as pyridine or triethylamine, and stirring the mixture for about 1 to about 24 hours at a temperature of about 0° to about 30° C. The product of the reaction, a pyridazinyl carbamate, is generally isolated by acidifying the reaction mixture, for instance by the addition of a mineral acid, such as hydrochloric acid or sulfuric acid, and collecting by filtration the precipitate which forms. The carbamate normally needs no further purification, but if desired it can be crystallized from common solvents, such as benzene, acetone, ethyl acetate, and the like.

후처리

  1. customThe product of the reaction

출처 및 근거

ORD 기록
ord-492eae2209534bc4af5cb4e1d76c9009
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04604127

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