Ammonium Hydroxide → 3-(5-tert-Butylpyridazin-3-yl)-4-hydroxy-1-methylimidazolidin-2-one

HRID 363988노트

반응식

HRID 363988 반응식
Cl[C:2]1[N:7]=[N:6][C:5]([N:8]2[CH:12]([OH:13])[CH2:11][N:10]([CH3:14])[C:9]2=[O:15])=[CH:4][C:3]=1[C:16]([CH3:19])([CH3:18])[CH3:17].[OH-].[NH4+].[H][H]>[Pd].C(O)C>[CH3:19][C:16]([C:3]1[CH:4]=[C:5]([N:8]2[CH:12]([OH:13])[CH2:11][N:10]([CH3:14])[C:9]2=[O:15])[N:6]=[N:7][CH:2]=1)([CH3:17])[CH3:18]

참가 물질

6

반응물 3

HCID 14923Ammonium HydroxideHCID 1759313-(5-tert-Butyl-6-chloropyridazin-3-yl)-4-hydroxy-1-methylimidazolidin-2-oneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 1637233-(5-tert-Butylpyridazin-3-yl)-4-hydroxy-1-methylimidazolidin-2-one수율 122.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of 2.0 g (0.00702 mole) of 3-[6-chloro-5-(1,1-dimethylethyl)-3-pyridazinyl]-4-hydroxy-1-methyl-2-imidazolidinone, 2.0 ml of concentrated ammonium hydroxide, 300 milligrams (mg) of 10% palladium on carbon, and 100 ml of 2B ethanol was placed on a Parr shaker apparatus at 50 pounds of hydrogen. After one hour, when the consumption of hydrogen exceeded the theoretical amount, the mixture was filtered and concentrated, giving 2.15 g of a white solid, which was partitioned between 400 ml of methylene chloride and 40 ml of water. The layers were separated and the organic layer was dried with magnesium sulfate.

후처리

  1. customwhen the consumption of hydrogen
  2. filtrationthe mixture was filtered
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-fb614abbd1fe4932bbe05fe870b19cd5
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04604127

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