1-(phenylmethyl)-N-propyl-3-pyrrolidinemethanamine → N-propyl-3-pyrrolidinemethanamine

HRID 364039노트

반응식

HRID 364039 반응식
C1(C[N:8]2[CH2:12][CH2:11][CH:10]([CH2:13][NH:14][CH2:15][CH2:16][CH3:17])[CH2:9]2)C=CC=CC=1.[H][H]>[Pd].CO>[CH2:15]([NH:14][CH2:13][CH:10]1[CH2:11][CH2:12][NH:8][CH2:9]1)[CH2:16][CH3:17]

참가 물질

5

반응물 2

HCID 142808851-(phenylmethyl)-N-propyl-3-pyrrolidinemethanamineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 13491799N-propyl-3-pyrrolidinemethanamine수율 83.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 14.0 g (60.0 mmole) of 1-(phenylmethyl)-N-propyl-3-pyrrolidinemethanamine, 1.0 g of 20% palladium on carbon and 140 ml of methanol was shaken in an atmosphere of hydrogen at about 50 psi and room temperature for 24 hours. The catalyst was removed by filtering through Celite, the filtrate concentrated and distilled in vacuo to give 7.1 g of N-propyl-3-pyrrolidinemethanamine, bp 49°-50° C./0.25 mm.

후처리

  1. customThe catalyst was removed
  2. filtrationby filtering through Celite
  3. concentrationthe filtrate concentrated
  4. distillationdistilled in vacuo

출처 및 근거

ORD 기록
ord-7172f5eca86e47e989170a876ccacf1e
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04604401

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