Thymine → Thymine

HRID 36404

반응식

HRID 36404 반응식
[OH-].[CH2:2]([N+:6]([CH2:15][CH2:16][CH2:17][CH3:18])([CH2:11][CH2:12][CH2:13][CH3:14])[CH2:7][CH2:8][CH2:9][CH3:10])[CH2:3][CH2:4][CH3:5].[NH:19]1[CH:27]=[C:25]([CH3:26])[C:23](=[O:24])[NH:22][C:20]1=[O:21]>CN(C)C=O>[CH2:15]([N+:6]([CH2:2][CH2:3][CH2:4][CH3:5])([CH2:7][CH2:8][CH2:9][CH3:10])[CH2:11][CH2:12][CH2:13][CH3:14])[CH2:16][CH2:17][CH3:18].[NH:19]1[CH:27]=[C:25]([CH3:26])[C:23](=[O:24])[NH:22][C:20]1=[O:21]

참가 물질

5

반응물 2

HCID 1135ThymineHCID 2723671Tetrabutylammonium Hydroxide

생성물 2

HCID 1135ThymineHCID 16028Tetrabutylammonium

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

1.5M Tetra(n-butyl)ammonium hydroxide (4.22 ml., 6.335 mmole) was added to a suspension of thymine (0.913 g., 7.24 mmole) in dimethylformamide (15 ml.). The mixture was stirred for 10 minutes, and the dimethylformamide was removed in vacuo. Additional dimethylformamide (20 ml.) was added to the white residue, and removed in vacuo. This process was repeated four times and the residue was dried under a vacuum (0.1 mm) at 50° C. overnight affording the tetra (n-butyl) ammonium salt of thymine.

후처리

  1. customthe dimethylformamide was removed in vacuo
  2. additionAdditional dimethylformamide (20 ml.) was added to the white residue
  3. customremoved in vacuo
  4. customthe residue was dried under a vacuum (0.1 mm) at 50° C. overnight

출처 및 근거

ORD 기록
ord-9563b5c96ba04b2ba694ef5e71cd858a
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05414096

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