1-(2-Hydrazinylethyl)pyrrolidine → 9-Methoxy-5-nitro-2-[2-(1-pyrrolidinyl)ethyl]-2H-[1]-benzopyrano[4,3,2-cd]indazole, monohydrochloride

HRID 364167

반응식

HRID 364167 반응식
[Cl:1][C:2]1[C:15]2[C:14](=O)[C:13]3[C:8](=[CH:9][CH:10]=[C:11]([O:17][CH3:18])[CH:12]=3)[O:7][C:6]=2[C:5]([N+:19]([O-:21])=[O:20])=[CH:4][CH:3]=1.[NH:22]([CH2:24][CH2:25][N:26]1[CH2:30][CH2:29][CH2:28][CH2:27]1)[NH2:23]>C1COCC1>[ClH:1].[CH3:18][O:17][C:11]1[CH:10]=[CH:9][C:8]2[O:7][C:6]3[C:15]4[C:14](=[N:23][N:22]([CH2:24][CH2:25][N:26]5[CH2:30][CH2:29][CH2:28][CH2:27]5)[C:2]=4[CH:3]=[CH:4][C:5]=3[N+:19]([O-:21])=[O:20])[C:13]=2[CH:12]=1

참가 물질

4

반응물 2

HCID 30315561-(2-Hydrazinylethyl)pyrrolidineHCID 136890881-Chloro-7-methoxy-4-nitro-9H-xanthen-9-one

생성물 1

HCID 1317148059-Methoxy-5-nitro-2-[2-(1-pyrrolidinyl)ethyl]-2H-[1]-benzopyrano[4,3,2-cd]indazole, monohydrochloride

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 12.2 g of 1-chloro-7-methoxy-4-nitro-9H-xanthen-9-one and 11.0 g of 1-(2-hydrazinoethyl)pyrrolidine in 200 ml of THF was stirred 20 hours at room temperature. The orange liquor was decanted, freed of solvent under reduced pressure, and the residue, in chloroform, was chromatographed over silica gel, eluting with chloroform-methanol (25:1 by volume). The desired fractions yielded the free base of the title compound, mp 140°-142° C.

후처리

  1. customThe orange liquor was decanted
  2. customthe residue, in chloroform, was chromatographed over silica gel
  3. washeluting with chloroform-methanol (25:1 by volume)

출처 및 근거

ORD 기록
ord-89315955443e42b683b57d0ac48944ff
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04604390

연결된 노트

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