Methanol → 1-chloro-7-hydroxy-4-nitro-9H-xanthen-9-one

HRID 364178노트

반응식

HRID 364178 반응식
[Cl:1][C:2]1[C:15]2[C:14](=[O:16])[C:13]3[C:8](=[CH:9][CH:10]=[C:11]([O:17]C)[CH:12]=3)[O:7][C:6]=2[C:5]([N+:19]([O-:21])=[O:20])=[CH:4][CH:3]=1.B(Br)(Br)Br.CO>ClCCl>[Cl:1][C:2]1[C:15]2[C:14](=[O:16])[C:13]3[C:8](=[CH:9][CH:10]=[C:11]([OH:17])[CH:12]=3)[O:7][C:6]=2[C:5]([N+:19]([O-:21])=[O:20])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 887MethanolHCID 25134Boron tribromideHCID 136890881-Chloro-7-methoxy-4-nitro-9H-xanthen-9-one

생성물 1

HCID 136890891-chloro-7-hydroxy-4-nitro-9H-xanthen-9-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A mixture of 10 g of 1-chloro-7-methoxy-4-nitro-9H-xanthen-9-one and 84 ml of a 1M solution of boron tribromide in dichloromethane in 280 ml of dichloromethane was stirred at room temperature under an argon atmosphere for 16 hours, and then it was treated with 100 ml of methanol, and stirred for three hours. The mixture was filtered to give a light green solid. Recrystallization from chloroformmethanol afforded the title compound, mp 290°-292° C.

후처리

  1. stirringstirred for three hours
  2. filtrationThe mixture was filtered
  3. customto give a light green solid
  4. customRecrystallization from chloroformmethanol

출처 및 근거

ORD 기록
ord-81c0d83bec0548e69712b630f7769f82
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04604390

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