Potassium Carbonate → 7-Tetradecenyl bromomethyl sulfone

HRID 364247

반응식

HRID 364247 반응식
[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH:7]=[CH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].[Br:15][CH2:16][S:17](Br)(=[O:19])=[O:18].C(=O)([O-])[O-].[K+].[K+]>C(Cl)Cl>[Br:15][CH2:16][S:17]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH:7]=[CH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])(=[O:19])=[O:18]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 25209Tetradec-7-eneHCID 10977482Bromomethanesulfonyl bromide

생성물 1

HCID 540523537-Tetradecenyl bromomethyl sulfone수율 100.7%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of 7-tetradecene (3.92 g) and bromomethanesulfonyl bromide (7.14 g) in methylene chloride (8 mL) was irradiated at -15° C. with an ultraviolet lamp for 2 hours. A small amount of solid potassium carbonate was added and then removed by filtration. The reaction mixture was diluted with methylene chloride (100 mL) and triethylamine (3.0 g) was added. The reaction mixture was heated on a steam bath for 1 hour. The reaction mixture was washed with dilute HCl and water. The methylene chloride layer was separated, dried over anhydrous magnesium sulfate and the methylene chloride removed in vacuo to give 7.1 g (100% yield) of oily 7-tetradecenyl bromomethyl sulfone which was characterized by IR and NMR spectroscopy.

후처리

  1. customwas irradiated at -15° C. with an ultraviolet lamp for 2 hours
  2. customremoved by filtration
  3. additionThe reaction mixture was diluted with methylene chloride (100 mL) and triethylamine (3.0 g)
  4. additionwas added
  5. temperatureThe reaction mixture was heated on a steam bath for 1 hour
  6. washThe reaction mixture was washed with dilute HCl and water
  7. customThe methylene chloride layer was separated
  8. dry with materialdried over anhydrous magnesium sulfate
  9. customthe methylene chloride removed in vacuo

출처 및 근거

ORD 기록
ord-a4fddf5a2d444dcea3d0886e2dffc783
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04604480

연결된 노트

불러오는 중…