1-Octene → 1-Octenyl bromomethyl sulfone

HRID 364248

반응식

HRID 364248 반응식
[CH2:1]=[CH:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[Br:9][CH2:10][S:11](Br)(=[O:13])=[O:12].C(=O)([O-])[O-].[K+].[K+]>C(Cl)Cl>[Br:9][CH2:10][S:11]([CH:1]=[CH:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])(=[O:13])=[O:12]

참가 물질

5

반응물 3

HCID 81251-OcteneHCID 11430Potassium CarbonateHCID 10977482Bromomethanesulfonyl bromide

생성물 1

HCID 543748991-Octenyl bromomethyl sulfone수율 97%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of 1-octene (2.82 g) and bromomethanesulfonyl bromide (6.0 g) in methylene chloride (4 mL) was irradiated at -20° C. with an ultraviolet lamp for 0.5 hours. A small amount of solid potassium carbonate was added and then removed by filtration. The reaction mixture was diluted with methylene chloride (50 mL), cooled in ice and treated with a solution of triethylamine (4.45 g) in 10 mL of methylene chloride. The reaction mixture was stirred for 0.25 hours and was washed with dilute HCl and water. The methylene chloride layer was separated, dried over anhydrous magnesium sulfate and the methylene chloride removed in vacuo to give 5.9 g (97% yield) of oily 1-octenyl bromomethyl sulfone which was characterized by IR and NMR spectroscopy.

후처리

  1. customwas irradiated at -20° C. with an ultraviolet lamp for 0.5 hours
  2. customremoved by filtration
  3. additionThe reaction mixture was diluted with methylene chloride (50 mL)
  4. temperaturecooled in ice
  5. additiontreated with a solution of triethylamine (4.45 g) in 10 mL of methylene chloride
  6. washwas washed with dilute HCl and water
  7. customThe methylene chloride layer was separated
  8. dry with materialdried over anhydrous magnesium sulfate
  9. customthe methylene chloride removed in vacuo

출처 및 근거

ORD 기록
ord-6d2a5b4874154d878d83e69241480c1f
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04604480

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