참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetone | HCID 180 | — |
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Methyl isocyanide | HCID 11646 | — |
| 반응물 | 2-Methylbenzoyl chloride | HCID 70276 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | N-methyl-2-(2-methylphenyl)-2-oxoacetamide | HCID 15239356 | — |
반응 단계
Methyl isocyanide (0.84 ml) was added to 2-methylbenzoyl chloride (1.55 g). The mixture was stirred at 60° C. for 16 hours. Then, 5N hydrochloric acid (1.5 ml) and acetone (2 ml) were added, and the mixture was stirred at room temperature for 1.5 hours for hydrolysis. Then, water was added. The mixture was extracted with methylene chloride, washed with water and dried. The solvent was evaporated under reduced pressure to obtain the title compound as an oil (1.68 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05414122 |
|---|
| 출처 데이터셋 | uspto-grants-1995_05 |
|---|
| ORD ID | ord-33cb00ace74546bf936022e8d0659d2b |
|---|
| 출처 메모 | uspto-grants-1995_05 |
|---|
