Acetone → N-methyl-2-(2-methylphenyl)-2-oxoacetamide

HRID 36428

반응식

HRID 36428 반응식
[CH3:1][N+:2]#[C-:3].[CH3:4][C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1[C:7](Cl)=[O:8].Cl.CC(C)=[O:17]>O>[CH3:3][NH:2][C:1](=[O:17])[C:7]([C:6]1[CH:10]=[CH:11][CH:12]=[CH:13][C:5]=1[CH3:4])=[O:8]

참가 물질

6

반응물 4

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 11646Methyl isocyanideHCID 702762-Methylbenzoyl chloride

생성물 1

HCID 15239356N-methyl-2-(2-methylphenyl)-2-oxoacetamide

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
60 °C

실험 절차

Methyl isocyanide (0.84 ml) was added to 2-methylbenzoyl chloride (1.55 g). The mixture was stirred at 60° C. for 16 hours. Then, 5N hydrochloric acid (1.5 ml) and acetone (2 ml) were added, and the mixture was stirred at room temperature for 1.5 hours for hydrolysis. Then, water was added. The mixture was extracted with methylene chloride, washed with water and dried. The solvent was evaporated under reduced pressure to obtain the title compound as an oil (1.68 g).

후처리

  1. stirringthe mixture was stirred at room temperature for 1.5 hours for hydrolysis
  2. extractionThe mixture was extracted with methylene chloride
  3. washwashed with water
  4. customdried
  5. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-33cb00ace74546bf936022e8d0659d2b
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05414122

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