Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl isothiocyanate → 2-[2-(2,2,2-Trifluoroethyl)guanidino]-6-[3-(3-methylthioureido)propylthio]pyrazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl isothiocyanate | HCID 11167 | — |
| 반응물 | 2-[2-(2,2,2-Trifluoroethyl)guanidino]-6-(3-aminopropylthio)pyrazine | HCID 21298819 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 2-[2-(2,2,2-Trifluoroethyl)guanidino]-6-[3-(3-methylthioureido)propylthio]pyrazine | HCID 21298784 | — |
반응 단계
A solution of 2-[2-(2,2,2-trifluoroethyl)guanidino]-6-(3-aminopropylthio)pyrazine in warm acetonitrile (15 ml.) was allowed to cool to room temperature. A solution of methylisothiocyanate (0.15 g.) in acetonitrile (1 ml.) was added and the mixture stirred overnight. Evaporation to dryness gave a yellow solid which was recrystallised from a small volume of ethyl acetate to yield 2-[2-(2,2,2-trifluoroethyl)guanidino]-6-[3-(3-methylthioureido)-propylthio]pyrazine (0.32 g.), m.p. 165°-167°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04604465 |
| 출처 데이터셋 | uspto-grants-1986_08 |
| ORD ID | ord-5c07f477c87a40b1bfda0e8f80d99176 |
| 출처 메모 | uspto-grants-1986_08 |