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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 36442생성일: 2026년 10월 26일

Water → 2-[Bis(4-benzyloxyphenyl)methyl]-N-(cyclooctyl)benzylamine

https://huagongshe.com/reaction/36442

반응식

참여 물질

역할이름HCID투입량
반응물WaterHCID 962—
반응물CyclooctylamineHCID 2903—
반응물Sodium borohydrideHCID 4311764—
반응물HCID 19938091HCID 19938091—
용매EthanolHCID 702—
생성물2-[Bis(4-benzyloxyphenyl)methyl]-N-(cyclooctyl)benzylamineHCID 1993812365.5%

반응 단계

In 50 ml of ethanol was dissolved 3 g of cyclooctylamine. To the solution was added 11.41 g of 2-[bis-(4-benzyloxyphenyl)methyl]benzaldehyde obtained by Reference Example 8, and the mixture was heated under reflux for 2 hours. Thereafter, 1.78 g of sodium borohydride was added thereto, and the mixture was heated under reflux for 2 hours. The solvent was evaporated-under reduced pressure, and water was added to the residue. The aqueous mixture was extracted with ether, and the organic layer was separated. The aqueous layer was extracted with ether, and then the organic layers were combined and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was recrystallized to afford 9.19 g of the desired product (Compound 82).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US05413997
출처 데이터셋uspto-grants-1995_05
ORD IDord-52c449ca1bc84ea98aa4feae94779a02
출처 메모uspto-grants-1995_05