O-Methylhydroxylamine hydrochloride → HCID 86740953, 화합물
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=O)[CH2:9][C:10]1[CH:15]=[N:14][CH:13]=[CH:12][N:11]=1.Cl.[CH3:18][O:19][NH2:20]>N1C=CC=CC=1>[CH3:18][O:19][N:20]=[C:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[Cl:1])[CH2:9][C:10]1[CH:15]=[N:14][CH:13]=[CH:12][N:11]=1참가 물질
4
실험 절차
3 g of 2'-chloro-2-(2-pyrazinyl)-acetophenone and 0.8 g of O-methylhydroxylamine hydrochloride are dissolved in 10 ml of pyridine and the mixture is heated at 80° for 30 minutes. The pyridine is then removed under reduced pressure and water is added to the crude product. Thereupon, the mixture is extracted with ethyl acetate and the organic phase is dried over sodium sulfate and concentrated to yield 2'-chloro-2-(2-pyrazinyl)-acetophenone O-methyl oxime as an oil.
후처리
- temperaturethe mixture is heated at 80° for 30 minutes
- customThe pyridine is then removed under reduced pressure and water
- additionis added to the crude product
- extractionThereupon, the mixture is extracted with ethyl acetate
- dry with materialthe organic phase is dried over sodium sulfate
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-d5aab528030d4a7dad87221b8528c5fb
- 출처 데이터셋
- uspto-grants-1986_08
- 특허 번호
- US04605656
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