Water → 2'-(Ethoxycarbonyloxy)4,4',6'-trimethoxychalcone

HRID 364659

반응식

HRID 364659 반응식
Cl[C:2]([O:4][CH2:5][CH3:6])=[O:3].OC1C=[C:24]([O:26][CH3:27])[CH:23]=[C:22]([O:28][CH3:29])[C:9]=1[C:10](=[O:21])[CH:11]=[CH:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=1.[OH2:30].N1[CH:36]=[CH:35]C=CC=1>>[CH2:35]([O:3][C:2]([O:4][C:5]1[CH:6]=[C:24]([O:26][CH3:27])[CH:23]=[C:22]([O:28][CH3:29])[C:9]=1[C:10](=[O:21])[CH:11]=[CH:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=1)=[O:30])[CH3:36]

참가 물질

5

반응물 4

HCID 962WaterHCID 1049PyridineHCID 10928Ethyl chloroformateHCID 235736Flavokavain A

생성물 1

HCID 537547452'-(Ethoxycarbonyloxy)4,4',6'-trimethoxychalcone수율 53%

실험 절차

Ethyl chloroformate (216 mg) was added dropwise to a solution of 2'-hydroxy-4,4',6'-trimethoxychalcone (314 mg) in 5 ml of pyridine. After stirring at room temperature for 30 minutes, the mixture was poured into water (30 ml). The mixture was extracted with three 30 ml portions of chloroform, and the combined extracts were washed with water, dried over Na2SO4 and evaporated to give an oily residue. Crystallization of the residue from methanol gave 202 mg (53% yield) of 2'-(ethoxycarbonyloxy)4,4',6'-trimethoxychalcone as pale yellow prisms; m.p. 107° C.

후처리

  1. extractionThe mixture was extracted with three 30 ml portions of chloroform
  2. washthe combined extracts were washed with water
  3. dry with materialdried over Na2SO4
  4. customevaporated
  5. customto give an oily residue
  6. customCrystallization of the residue from methanol

출처 및 근거

ORD 기록
ord-886c005a8ab34ef0b612cdf910c5845e
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04605674

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