Barium → 4-(1H-Imidazol-2-yl)-pyridine
반응식
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[NH:8][CH2:9][CH2:10][N:11]=2)=[CH:3][CH:2]=1.[Ba]>C(Cl)Cl>[NH:8]1[CH:9]=[CH:10][N:11]=[C:7]1[C:4]1[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=1참가 물질
4
실험 절차
2-(4-pyridyl)-imidazoline (7.0 g, 0.047M) and barium mangnate (52.5 g) in CH2Cl2 (500 ml) were refluxed with stirring for 24 hrs. The reaction mixture was then filtered through diatomaceous earth, washed with methylene chloride and then ethylacetate. The combined filtrates were concentrated and crystallized from ethylacetate-petroleum ether to give 4-(1H-imidazol-2-yl)pyridine (4.7 g, 67% yield).
후처리
- filtrationThe reaction mixture was then filtered through diatomaceous earth
- washwashed with methylene chloride
- concentrationThe combined filtrates were concentrated
- customcrystallized from ethylacetate-petroleum ether
출처 및 근거
- ORD 기록
- ord-8d2006b4e8cb47d7b5b819625280b916
- 출처 데이터셋
- uspto-grants-1986_08
- 특허 번호
- US04605744
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