Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenoxyacetyl chloride → Ethyl 4-(1-oxo-2-phenoxyethylamino)butanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenoxyacetyl chloride | HCID 69703 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 4-Aminobutyrate ethyl hydrochloride | HCID 12649661 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | Ethyl 4-(1-oxo-2-phenoxyethylamino)butanoate | HCID 53983334 | 53% |
반응 단계
To a stirred mixture of ethyl 4-aminobutanoate hydrochloride (3.4 g) and phenoxyacetyl chloride (2.76 ml) in 50 ml of Et2O and 50 ml of water was added one portion of NaHCO3 (4.2 g). After 2 hr the layers were separated and the organic phase was washed (1N HCl, brine), dried (MgSO4), and filtered. Evaporation of the solvent under vacuum gave 3.1 g (53%) of the title compound as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05414132 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-98d2491207f3486cb4bc46f3b8953d73 |
| 출처 메모 | uspto-grants-1995_05 |